Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.204


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_31242593-0.292.7e-01Click!
SOX2chr3_+_1829127690.136.3e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_100714995 1.100 MTTP
microsomal triglyceride transfer protein
chr5_+_27508139 1.067 LOC643401
hypothetical protein LOC643401
chr10_+_7785235 0.967 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 0.966 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 0.956 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_24394281 0.956 PIPOX
pipecolic acid oxidase
chr10_+_7785360 0.947 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_-_17797127 0.904 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr11_-_117552545 0.873 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr12_-_7547552 0.859 NM_004244
NM_203416
CD163

CD163 molecule

chr16_-_54424517 0.830 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr6_+_32515596 0.818 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_-_156904690 0.805 NM_014996
PLCH1
phospholipase C, eta 1
chr4_+_74493174 0.799 ALB
albumin
chr2_+_36777336 0.741 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr12_+_7755316 0.734 NM_199286
DPPA3
STELLAR
developmental pluripotency associated 3
developmental pluripotency associated 3 pseudogene
chr4_+_74493918 0.714 ALB
albumin
chr1_+_61315516 0.709 NM_001145511
NFIA
nuclear factor I/A
chr20_+_16312 0.705 NM_153325
DEFB125
defensin, beta 125
chr17_+_24394043 0.701 NM_016518
PIPOX
pipecolic acid oxidase
chr17_-_25685175 0.693 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr17_-_64649608 0.691 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr6_+_132000134 0.688 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr18_-_73834670 0.644


chr6_+_24465109 0.629 NM_181337
KAAG1
kidney associated antigen 1
chr4_+_74493331 0.614 ALB
albumin
chr9_-_14900992 0.603 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr5_+_118993152 0.599 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr7_-_16471817 0.596 NM_015464
SOSTDC1
sclerostin domain containing 1
chr4_+_187424111 0.591 NM_000128
F11
coagulation factor XI
chr11_-_117552355 0.578 SCN2B
sodium channel, voltage-gated, type II, beta
chr6_+_167445284 0.570 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr1_-_150328153 0.568 NM_001008536
TCHHL1
trichohyalin-like 1
chr18_-_59462469 0.567 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr4_+_74493266 0.562 ALB
albumin
chr4_+_74493218 0.560 ALB
albumin
chr7_+_29486010 0.557 NM_001039936
CHN2
chimerin (chimaerin) 2
chrX_-_138875342 0.552 NM_001013403
CXorf66
chromosome X open reading frame 66
chr12_-_14887648 0.547 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr12_-_14982708 0.532 NM_152321
ERP27
endoplasmic reticulum protein 27
chr14_-_19252330 0.531 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr7_-_122422989 0.526 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr15_+_38296920 0.513 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr3_-_174341653 0.505 NM_031955
SPATA16
spermatogenesis associated 16
chr4_+_187424336 0.505 F11
coagulation factor XI
chr7_+_37689903 0.504


chr4_-_70861301 0.504 NM_001891
CSN2
casein beta
chr13_-_85271329 0.503 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr4_+_74493301 0.502 ALB
albumin
chr10_-_69267774 0.495 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr5_+_76150637 0.495 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr12_-_9123126 0.495 A2M
alpha-2-macroglobulin
chr6_-_43384507 0.488 NM_206922
CRIP3
cysteine-rich protein 3
chr14_-_105610144 0.479 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr11_+_110631916 0.469 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr14_+_38772870 0.465 NM_054024
MIA2
melanoma inhibitory activity 2
chr6_-_138862273 0.449


chr4_+_88939725 0.443 NM_004967
IBSP
integrin-binding sialoprotein
chr10_-_52315436 0.442 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_-_5035967 0.435 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr1_+_50347176 0.435 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr1_+_81544432 0.429 LPHN2
latrophilin 2
chr6_-_50045296 0.427 NM_001037729
DEFB113
defensin, beta 113
chr8_+_142501188 0.426 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr16_+_70646008 0.426 NM_001126102
NM_005143
HP

haptoglobin

chr14_-_106330781 0.417 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr2_-_215949566 0.409 FN1
fibronectin 1
chr11_-_55987452 0.404 NM_001004743
OR5M9
olfactory receptor, family 5, subfamily M, member 9
chr6_+_123142559 0.403 FABP7
fatty acid binding protein 7, brain
chr1_+_86785346 0.400 NM_012128
CLCA4
chloride channel accessory 4
chr8_-_7710547 0.395 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr2_+_138438277 0.394 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr13_-_27441290 0.394 NM_001265
CDX2
caudal type homeobox 2
chr11_-_62508946 0.392 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr4_-_110942783 0.391 NM_000204
CFI
complement factor I
chr21_+_41663853 0.390 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr18_+_27152049 0.382 NM_001942
DSG1
desmoglein 1
chr14_-_20098929 0.381 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr4_+_154397975 0.379 TRIM2
tripartite motif containing 2
chr11_-_35398077 0.378 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_+_61569136 0.375 NM_004361
CDH7
cadherin 7, type 2
chr7_-_107230867 0.375 NM_000111
SLC26A3
solute carrier family 26, member 3
chr12_+_47162552 0.373 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr2_+_113601616 0.371 IL1RN
interleukin 1 receptor antagonist
chrX_-_100920493 0.371 GK
glycerol kinase
chr10_+_96512447 0.367 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr5_+_76150588 0.367 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr3_-_42892195 0.366 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr6_+_10693964 0.362 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr19_-_53081326 0.361 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr6_-_88917600 0.358 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr10_+_4995685 0.357 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr11_-_128242342 0.355 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr15_+_22652790 0.354 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr4_+_140806536 0.353 MGST2
microsomal glutathione S-transferase 2
chr21_-_38415273 0.353 NM_005867
DSCR4
Down syndrome critical region gene 4
chr3_+_99555387 0.351 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr6_+_47857733 0.348 NM_181744
OPN5
opsin 5
chrX_-_101613387 0.347 NM_017809
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr10_+_77212524 0.342 NM_032024
C10orf11
chromosome 10 open reading frame 11
chrX_+_141941369 0.336 NM_001009613
SPANXN4
SPANX family, member N4
chr2_+_113601608 0.334 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr12_-_129212720 0.328 FLJ31485
hypothetical LOC440119
chr12_+_7833261 0.327 NM_024865
NANOG
Nanog homeobox
chrX_+_87888881 0.325 NM_001184771
NM_033048
CPXCR1

CPX chromosome region, candidate 1

chr1_+_559618 0.323


chr1_-_161380562 0.323 RGS5
regulator of G-protein signaling 5
chrX_+_101356905 0.322 NM_017809
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr6_-_49862858 0.320 NM_138733
PGK2
phosphoglycerate kinase 2
chr7_-_36730525 0.319 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr10_+_7785347 0.315 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_21079145 0.314 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_-_173723754 0.312 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr20_+_18742369 0.308 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr11_-_57927457 0.308 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr1_+_34098662 0.304 NM_145205
HMGB4
high-mobility group box 4
chr14_-_106154332 0.302 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_21177529 0.298 NM_021068
IFNA4
interferon, alpha 4
chr9_+_134843918 0.297 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr11_-_6005546 0.294 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr1_+_50347188 0.291 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_68995761 0.290 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr8_-_82557956 0.287 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr7_-_122126422 0.287 NM_139175
RNF133
ring finger protein 133
chr2_+_234265059 0.284 NM_205862
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr20_-_9767406 0.284 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr8_+_39890484 0.281 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr12_+_21059896 0.279 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr4_-_68793928 0.279 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr3_-_172227461 0.272 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr6_-_66346417 0.269 NM_198283
EYS
eyes shut homolog (Drosophila)
chr1_+_6226838 0.268 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr2_+_169367345 0.267 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr20_-_31055892 0.267 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr10_+_4995597 0.261 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr6_-_119512035 0.260 NM_001100411
FAM184A
family with sequence similarity 184, member A
chrX_+_111005934 0.257 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chr1_-_93172119 0.255


chr10_-_98109048 0.251 NM_001040102
NM_001040103
NM_033207
OPALIN


oligodendrocytic myelin paranodal and inner loop protein


chr2_-_219614481 0.251 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr1_+_61315378 0.249


chrX_+_79562601 0.248 NM_152630
FAM46D
family with sequence similarity 46, member D
chr4_+_70928718 0.247 NM_000200
HTN3
histatin 3
chr19_-_62370667 0.246 NM_001012729
DUXA
double homeobox A
chr1_-_100003936 0.240 NM_001013660
FRRS1
ferric-chelate reductase 1
chr1_-_175400441 0.239 ASTN1
astrotactin 1
chr12_+_7833292 0.237 NANOG
Nanog homeobox
chr2_-_215998181 0.237 FN1
fibronectin 1
chr2_+_87536174 0.237 NCRNA00152
non-protein coding RNA 152
chr11_+_113280727 0.236 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr10_+_4995453 0.235 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_+_68445821 0.234 NM_002664
PLEK
pleckstrin
chr21_-_44911250 0.233 NM_181684
KRTAP12-2
keratin associated protein 12-2
chr11_-_16380967 0.231 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr12_+_54106304 0.226 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr12_+_38306238 0.224 NM_001031748
C12orf40
chromosome 12 open reading frame 40
chr11_-_5980953 0.223 NM_001005179
OR56A4
olfactory receptor, family 56, subfamily A, member 4
chr3_+_2908920 0.223 NM_175613
CNTN4
contactin 4
chr15_-_32118477 0.222 NM_020371
AVEN
apoptosis, caspase activation inhibitor
chr11_-_82289006 0.222 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr14_-_105804211 0.220 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_89223666 0.218 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr5_-_43448174 0.217 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr7_-_100092003 0.217 NM_016188
ACTL6B
actin-like 6B
chr19_-_5789740 0.216 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr11_+_62813947 0.216 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr6_+_55147029 0.213 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr1_-_156954528 0.210 NM_001005327
OR6K3
olfactory receptor, family 6, subfamily K, member 3
chr4_+_71096830 0.210 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr9_-_103185621 0.210 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr10_-_96819064 0.210 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr21_-_30836051 0.208 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr12_+_111829191 0.208 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_559129 0.203


chr5_+_79366746 0.203 NM_003248
THBS4
thrombospondin 4
chrX_+_150653873 0.203 NM_005140
CNGA2
cyclic nucleotide gated channel alpha 2
chr2_-_152392935 0.203 ARL5A
ADP-ribosylation factor-like 5A
chr6_+_29249289 0.202 NM_030905
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr3_+_99334230 0.202 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr21_-_30884586 0.200 NM_001164434
KRTAP22-2
keratin associated protein 22-2
chr6_+_27400518 0.197 NM_032030
FKSG83
FKSG83
chr20_-_44151971 0.197 NM_020967
NCOA5
nuclear receptor coactivator 5
chr20_+_20296744 0.196 NM_002196
INSM1
insulinoma-associated 1
chr1_+_31823097 0.195 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr11_-_56067308 0.195 NM_001005245
OR5M11
olfactory receptor, family 5, subfamily M, member 11
chrX_+_90977115 0.194 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr10_-_123346148 0.194 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chrX_-_123925343 0.193 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr3_+_99370233 0.193 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr21_+_30910614 0.192 NM_181615
KRTAP20-1
keratin associated protein 20-1
chr5_+_161210280 0.192 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr14_-_92721012 0.192 MOAP1
modulator of apoptosis 1
chr5_-_147142368 0.191 JAKMIP2
janus kinase and microtubule interacting protein 2
chr4_-_68511738 0.191 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr10_+_123744131 0.191 TACC2
transforming, acidic coiled-coil containing protein 2
chrX_+_71280758 0.190 NM_207422
FLJ44635
TPT1-like protein
chr14_-_105796665 0.189 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr12_+_25096755 0.189 LRMP
lymphoid-restricted membrane protein
chr1_-_151296611 0.189 NM_005988
SPRR2A
small proline-rich protein 2A
chr2_+_143351695 0.189 KYNU
kynureninase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.19 1.57e-11 GO:0007606 sensory perception of chemical stimulus
3.24 1.29e-10 GO:0007608 sensory perception of smell
1.37 5.04e-09 GO:0050896 response to stimulus
2.26 2.07e-07 GO:0007600 sensory perception
6.11 1.93e-05 GO:0072376 protein activation cascade
1.79 6.44e-05 GO:0050877 neurological system process
1.32 1.56e-04 GO:0032501 multicellular organismal process
1.66 2.25e-04 GO:0003008 system process
6.67 6.75e-04 GO:0031214 biomineral tissue development
1.95 2.90e-03 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.69 1.15e-07 GO:0005576 extracellular region
1.41 6.34e-07 GO:0071944 cell periphery
1.41 8.14e-07 GO:0005886 plasma membrane
1.25 2.15e-03 GO:0031224 intrinsic to membrane
1.24 2.93e-03 GO:0016021 integral to membrane
1.78 5.35e-03 GO:0005615 extracellular space
1.66 8.02e-03 GO:0044421 extracellular region part
1.20 1.10e-02 GO:0044425 membrane part
1.15 3.83e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.36 9.41e-16 GO:0004888 transmembrane receptor activity
2.65 4.09e-14 GO:0004930 G-protein coupled receptor activity
1.98 9.09e-12 GO:0004872 receptor activity
3.33 1.88e-11 GO:0004984 olfactory receptor activity
1.77 1.92e-09 GO:0004871 signal transducer activity
1.77 1.92e-09 GO:0060089 molecular transducer activity